Looking for: Alcohol with prednisone - Click here Should I Avoid Alcohol When Taking Prednisone? July 15, Jackie Daniels. You might be wondering if you can still have a glass Alcohol When on Prednisone. If your dose is low and you are not using prednisone to treat chronic conditions such as rheumatoid arthritis or adrenal insufficiency, one or two drinks per day should be OK. However, patients under long-term treatment with this drug can be exposed to severe health problems, osteoporosis, weakened immune system, and other serious health risks. Prednisone is a synthetic form of an adrenocortical steroid that medical experts prescribe to treat various diseases. It can help regulate hormones in individuals whose adrenal glands do not generate enough corticosteroids. Prednisone is classified as a corticosteroid medication. These potent anti-inflammatories can be used to treat the conditions that cause inflammation, such as arthritis, multiple sclerosis, and lupus. Additiona