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Azithromycin taken with prednisone.The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease
- Can You Take Prednisone With Azithromycin? | HelloPharmacist
Steroids and antibiotics prescribed together: New trend?.
Federal Government. Read our disclaimer for details. Recruitment status was: Not yet recruiting First Posted : November 10, Last Update Posted : November 11, Study Description.
Corticosteroids may be effective in the treatment of CSD for the following reasons: Many experts believe that host response is involved in the pathogenesis of CSD and is responsible for the clinical manifestations rather than the direct effect of B. The absence of viable organisms in affected lymph nodes in the presence of positive PCR for B.
Corticosteroids have been anecdotally reported to have been administered to patients with CSD, apparently with some success. The purpose of this study is to evaluate the efficacy of corticosteroids in addition to azithromycin in CSD. The study hypothesis is that corticosteroids will improve out come. Patients will be under followed up for 3 months. Major outcome measures will include duration of symptoms and signs, with particular emphasis on affected lymph node size and duration using a specific scoring system lymphadenitis score, LS.
LS will be used to evaluate lymphadenitis at each follow-up visit. The historical control group will be consisted of age, sex, and clinical manifestations-matched CSD patients who were treated with azithromycin without corticosteroids. Drug Information available for: Azithromycin Azithromycin dihydrate Azithromycin monohydrate. FDA Resources. Arms and Interventions. Intervention Details: Drug: prednison and azithromycin Patients with typical cat-scratch disease will be treated with a 5-day course of prednison and azithromycin.
Outcome Measures. Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Ability and willingness to comply with the protocol. Male and female patients aged years at the time of signing informed consent. Patients with clinical manifestations consistent with early typical cat scratch disease lymphadenitis before spontaneous improvement has been recorded and before development of suppuration.
Known history of allergy, hypersensitivity, or any serious reaction to azithromycin, other macrolides or corticosteroids. Patients for whom azithromycin or corticosteroids is contra-indicated. Current treatment with systemic corticosteroids. Patients with typical late cat scratch disease who has demonstrated constant improvement in the clinical manifestations of the involved lymph node.
Atypical cat scratch disease e. Endocarditis due to Bartonella sp.. Diabetes mellitus. Peptic ulcer disease or history of upper GI bleeding. History of inadequately treated tuberculosis or evidence of tuberculosis in the chest radiography. Schizoaffective disorder, anxiety or depression treated with antipsychiatric drugs, at present or in the past. Treatment with any investigational drug in any clinical trial within 30 days prior to administration of study medication.
Antibiotics work a bit differently. So, for example, you might take an antibiotic to fight an infection such as strep throat, an ear infection, or a sinus infection. There are many different classes and types of antibiotics; talk with your doctor about the right one for you. The answer to this question depends on the specific steroid, antibiotic, and the infection—but yes, in some cases, your physician may prescribe both drugs at the same time.
The antibiotic targets bacteria and the steroid controls inflammation and resulting pain. For example, the steroid dexamethasone has proven effective in adults with bacterial meningitis, according to a study in The New England Journal of Medicine.
The two are also often prescribed together for certain infections. Still, there are some potential interactions you should be aware of when taking both oral steroids and antibiotics.
Here are common ones to be mindful of. Always talk with your provider if you are unsure about drug interactions or have follow-up questions. There is a potential interaction between dexamethasone, a type of steroid, and certain antibiotics.
The antibiotic erythromycin can raise the amount of dexamethasone in your system, increasing your risk of side effects. All corticosteroids, including prednisone, carry the risk of interacting with quinolone antibiotics levofloxacin, ciprofloxacin and causing a tendon tissue that connects muscle to bone to rupture. Mixing prednisone and penicillin antibiotics such as amoxicillin is considered safe, says Madison.
Alcohol can increase your risk of side effects while on certain medications. You should avoid alcohol while taking certain antibiotics such as Flagyl metronidazole , Tindamax tinidazole , and Bactrim sulfamethoxazole. The combo can result in nausea, vomiting, rapid heart rate, and headaches. There are no known interactions between alcohol and steroids such as prednisone but drinking large amounts of alcohol may increase your side effects, including an upset stomach.
To be safe, avoid drinking while taking oral steroids or at the very least, limit your intake. Every drug carries a risk of side effects, and steroids and antibiotics are no different.
But in the case of these two drugs, the gastrointestinal side effects can be worse when combined. For example, common side effects of antibiotics are nausea, diarrhea, and upset stomach. Corticosteroids can also cause an upset stomach and cramping , as they irritate the stomach lining.
So in short, combining antibiotics and steroids may increase the risk of stomach issues.
Dear Dr. Roach: In late spring ofI had a sinus infection and was prescribed both an antibiotic and prednisone. I was told that the steroid would increase the effectiveness of the antibiotic. After reading the patient insert for prednisone, I elected to take only the antibiotic, with excellent results. Since that time, three of my friends also were prescribed antibiotics by three different doctors for various conditions; all were also prescribed prednisone to take with it.
Two of them did take the prednisone, resulting in really unpleasant side effects. This week I went to another doctor, was diagnosed with acute nasopharyngitis and was told to take an antibiotic and prednisone. When I said I didn't want to take the prednisone, the doctor informed me that he never prescribes antibiotics without prednisone.
I was prescribed clindamycin and methylprednisolone. I again elected not to take the steroid. Can you tell me if this dual prescribing is a widespread medical trend or just a local one? Is there really a good reason for prescribing antibiotics and prednisone together, and am I being foolish not to follow doctor's orders? Dear E. These studies have shown a speedier recovery in those taking the combination of steroids and antibiotics than in those who take antibiotics alone, and I suspect that is why your doctors, and those of your friends, have been prescribing them.
However, there is a downside to steroids, as you note. It's not just the unpleasant immediate side effects, such as jitteriness and difficulty sleeping; steroids can have serious side effects in the short term confusion and even psychosis are well known.
In the long term, the list of possible side effects is very long, so the benefit must always be weighed against the possible harm. This is particularly the case in people at high risk for side effects, such as diabetics in whom sugar levels routinely go up when taking steroids or those with high blood pressure which often is exacerbated by steroid use.
Personally, I prefer to use nasal steroids in combination with antibiotics. They have many of the benefits of oral steroids with few of the side effects. Nasal steroids don't work as quickly as oral steroids, however. In any case, I can't condone you not following your doctor's recommendations. I certainly do recommend that you have a discussion about the benefits versus the harms, and I'd also recommend that you ask about nasal steroids. Roach: I have read that atrial fibrillation gives you a greater chance of getting dementia.
Do you agree? Dear K. However, it's not clear if the atrial fibrillation causes dementia or whether it is because some of the risks for developing dementia are also risks for developing atrial fibrillation.
What is clear is that people who are not treated well for atrial fibrillation specifically, those people whose anticoagulation dosage is frequently too much or too little have a greater risk for dementia than those whose atrial fibrillation is well-controlled. This is yet another reason that both patients and doctors should take particular care with anticoagulation. It isn't clear whether the newer anticoagulant drugs will have less risk of dementia.
View Comments View Comments. It isn't clear whether the newer anticoagulant drugs will have less risk of dementia — Readers may email questions to ToYourGoodHealth med.
Prednisone, a corticosteroid, can suppress the immune system and. The purpose of this study is to evaluate the efficacy of corticosteroids in addition to azithromycin in CSD. The study hypothesis is that corticosteroids. Severe Interactions. These medications are not usually taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Azithromycin is a macrolide antibiotic used to treat a variety of bacterial Prednisone acetate, The metabolism of Azithromycin can be increased when. Prednisone, a corticosteroid, can suppress the immune system and. The purpose of this study is to evaluate the efficacy of corticosteroids in addition to azithromycin in CSD. Outcome Measures. Arms and Interventions. Azithromycin belongs to the class of drugs known as macrolide antibiotics. FDA Resources. Measure your dose correctly with a marked measuring spoon, oral syringe, or medicine cup.Study record managers: refer to the Data Element Definitions if submitting registration or results information. Bartonella henselae is the etiologic agent of cat scratch disease CSD. In most CSD cases resolution occurs in 2 to 3 months although a prolonged course often occurs.
Data on the efficacy of antibiotic therapy in CSD is limited. Azithromycin has been shown to have a small favorable effect in a small comparative study and is commonly prescribed for CSD, however its overall effect is not satisfactory. Corticosteroids may be effective in the treatment of CSD for the following reasons:.
The total score will consist of the arithmetical summation of the 5 parameters. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below.
For general information, Learn About Clinical Studies. We're building a better ClinicalTrials. Check it out and tell us what you think! Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information.
Search for terms. Save this study. Warning You have reached the maximum number of saved studies The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U. Federal Government. Read our disclaimer for details.
Recruitment status was: Not yet recruiting First Posted : November 10, Last Update Posted : November 11, Study Description. Corticosteroids may be effective in the treatment of CSD for the following reasons: Many experts believe that host response is involved in the pathogenesis of CSD and is responsible for the clinical manifestations rather than the direct effect of B.
The absence of viable organisms in affected lymph nodes in the presence of positive PCR for B. Corticosteroids have been anecdotally reported to have been administered to patients with CSD, apparently with some success. The purpose of this study is to evaluate the efficacy of corticosteroids in addition to azithromycin in CSD.
The study hypothesis is that corticosteroids will improve out come. Patients will be under followed up for 3 months. Major outcome measures will include duration of symptoms and signs, with particular emphasis on affected lymph node size and duration using a specific scoring system lymphadenitis score, LS.
LS will be used to evaluate lymphadenitis at each follow-up visit. The historical control group will be consisted of age, sex, and clinical manifestations-matched CSD patients who were treated with azithromycin without corticosteroids. Drug Information available for: Azithromycin Azithromycin dihydrate Azithromycin monohydrate. FDA Resources. Arms and Interventions. Intervention Details: Drug: prednison and azithromycin Patients with typical cat-scratch disease will be treated with a 5-day course of prednison and azithromycin.
Outcome Measures. Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Ability and willingness to comply with the protocol.
Male and female patients aged years at the time of signing informed consent. Patients with clinical manifestations consistent with early typical cat scratch disease lymphadenitis before spontaneous improvement has been recorded and before development of suppuration. Known history of allergy, hypersensitivity, or any serious reaction to azithromycin, other macrolides or corticosteroids. Patients for whom azithromycin or corticosteroids is contra-indicated. Current treatment with systemic corticosteroids.
Patients with typical late cat scratch disease who has demonstrated constant improvement in the clinical manifestations of the involved lymph node. Atypical cat scratch disease e. Endocarditis due to Bartonella sp.. Diabetes mellitus. Peptic ulcer disease or history of upper GI bleeding. History of inadequately treated tuberculosis or evidence of tuberculosis in the chest radiography.
Schizoaffective disorder, anxiety or depression treated with antipsychiatric drugs, at present or in the past. Treatment with any investigational drug in any clinical trial within 30 days prior to administration of study medication. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials. More Information. National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Cat-scratch Disease Bartonella Infections. Drug: prednison and azithromycin Drug: prednison, azithromycin Drug: prednison, Azenil.
Phase 4. Study Type :. Interventional Clinical Trial. Estimated Enrollment :. Study Start Date :. Estimated Primary Completion Date :. November 10, Key Record Dates.
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